Tohoku Univ. Technology：Improvement of Filamentous Fungi Using TAQing System：T22-154
Production of secondary metabolites derived from fungal dormancy genes
Many drugs have been developed from natural products produced by filamentous fungi. On the other hand, it has been reported that many biosynthetic genes of unexplored natural products that can be candidates for drugs are dormant on the genome of filamentous fungi. Using a large-scale genome rearrangement technology "TAQing system (A technique in which the restriction enzyme TAQI is introduced into a cell to simultaneously and multiply break DNA double strands, followed by recombination repair to produce a variety of genomic rearrangements)," the inventors generated a number of mutant strains of filamentous fungi in which dormant biosynthetic genes were activated, and succeeded in remarkably inducing the production of natural products not produced by wild strains. The development of a secondary metabolic activation method using the TAQing system has been investigated using the model filamentous fungus Aspergillus nidulans.
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
